The last time the Panthers and Broncos played was in Week 10 of the 2012 season at Carolina, and Denver cruised to a 36–14 win in then head coach John Fox’s first game back in the stadium where he coached from 2002 through 2010. Peyton Manning threw for over 300 yards (something he's done just once this season but did nine times in 2012), while second-year quarterback Cam Newton threw for two touchdowns and two interceptions. Denver's defense put Newton on the ground seven times, and the entire Panthers team ran for just 52 yards on 21 carries.
Things have obviously changed pretty significantly over the last few years.