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The top running back in our rankings this week (heading into Monday Night Football) is Carolina's Christian McCaffrey, who ran for 64 yards and a touchdown against the stout New Orleans Saints defense, adding 69 more yards and another touchdown as a receiver. Thanks to a healthy boost in opponent adjustments, he finishes on top of the running back pile for the second week in a row, and for the fourth time this season. He has also finished in second place twice. (Oddly, he was in last place in Week 2, but that was without full-strength opponent adjustments; now that we know how good Tampa Bay's run defense is, it's safe to say that McCaffrey's game against the Bucs was better than it looked at the time.