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Niners' Williams, Pearsall out vs. Seahawks; Kittle to play

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SANTA CLARA, Calif. -- The San Francisco 49ers' offense will be without two of its biggest contributors -- left tackle Trent Williams and receiver Ricky Pearsall -- for Saturday night's showdown against the Seattle Seahawks.

Williams' absence was expected after he didn't practice all week because of a right hamstring injury. Pearsall's is a bit more surprising because he was a limited participant in practice each day despite right knee and ankle injuries.