ESPN.com · Oct 11, 2025
NFL Week 6 predictions, fantasy sleepers, upset picks, bets
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Week 6 of the 2025 NFL season is here, and our NFL analysts have you covered on last-minute prep. Catch up on everything before Sunday's action.
Here's what we have: First, analytics writer Seth Walder breaks down three stat trends that could be pivotal this weekend. Then fantasy football writer Eric Moody runs through five players who are rostered in under 50% of ESPN fantasy football leagues as of Saturday and could be started in a jam. That's followed by NFL analyst Matt Bowen predicting three potentially big surprises and sports betting analyst Pamela Maldonado giving her favorite bet for Week 6.
