Our NFL Insiders predict Week 6's biggest upsets and fantasy flops and sleepers. Plus: Should Pittsburgh fans be worried about Ben Roethlisberger? Are the Packers the best one-loss team?
What's your top upset pick for Week 6?
Matt Bowen, NFL writer: Rams over Jaguars. That Jacksonville secondary is nasty. Jalen Ramsey and A.J. Bouye will challenge every throw from Jared Goff; they're physical cornerbacks with ball skills. However, can the Rams lean on a high-volume day from Todd Gurley and take some calculated shots up the seam versus the Jags' Cover 3 shell?