New Orleans Saints running back Mark Ingram will not play Thursday's game against the Buffalo Bills, per Fox Sports' Jay Glazer.
That leaves Tony Jones, Dwayne Washington and Ty Montgomery as the remaining running backs for the NFC South team since Alvin Kamara is also sidelined.
The 31-year-old Ingram dealt with an ankle issue last season with the Baltimore Ravens after injuring it in Week 6 against the Philadelphia Eagles, though it happened to correspond with the team's Week 7 bye, lessening the time he missed.
For the season, he rushed for 299 yards and two scores in 11 games.