The San Francisco 49ers lost more than the game to the Denver Broncos on Sunday.
Head coach Kyle Shanahan told reporters that left tackle Trent Williams likely suffered a high ankle sprain in the 11-10 defeat. He exited the game in the third quarter on a disastrous play for the 49ers that saw Jimmy Garoppolo step out of the back of the end zone for a safety when he dropped back to pass deep in his own territory.
Colton McKivitz initially came in at left tackle to replace him, but the 49ers then switched to Jaylon Moore later in the contest.