Mohammed Salisu is back in contention for Southampton after a two-match absence because of a hamstring issue.
Nathan Tella has returned to training but is not ready to play, while Lyanco is still sidelined by a thigh problem.
Newcastle forward Allan Saint-Maximin, who featured as a substitute against Brighton after missing two games with a calf injury, is not yet 100% fit.
Matt Ritchie is available but Isaac Hayden, Callum Wilson and Kieran Trippier remain sidelined.
MATCH FACTS
Head-to-head
- Newcastle lost 2-0 away to Southampton last season but that is their only defeat in the past nine meetings.