Saracens include Mako Vunipola in their starting XV for the first time this season after being given extra time off following his efforts with the British & Irish Lions in the summer.
Wing Sean Maitland (knee) will also make his first start this campaign.
Newcastle Falcons will give a debut to veteran Mike Brown after he missed their first three games with a rib injury.
Brown is one of five changes from the team that beat Wasps 18-14.
Saracens wing Alex Lewington:
"It's going to be a really special occasion on Saturday.