Newcastle trio Kieran Trippier, Harvey Barnes and Tino Livramento could all return after injury.
Defender Sven Botman will miss the rest of the season after knee surgery and Lewis Miley is out with a back problem.
West Ham's Edson Alvarez starts a two-match ban for accruing 10 yellow cards.
Lucas Paqueta and Nayef Aguerd need to be assessed, while Maxwel Cornet is back in training after six weeks out with a hamstring injury but lacking match fitness.
Mohammed Kudus, who missed Ghana's matches in the international break with a knee injury, is also being monitored.