Newcastle midfielder Joelinton faces at least six weeks out after suffering a thigh injury last weekend.
He joins a long list of absentees, including Nick Pope, Callum Wilson, Harvey Barnes and Joe Willock.
Manchester City midfielder Kevin De Bruyne is set to feature again after making his long-awaited comeback during the FA Cup win over Huddersfield.
Erling Haaland remains out with a foot injury but Jack Grealish could return after suffering illness in the week.
John Stones is still sidelined with an ankle injury.
MATCH FACTS
Head-to-head
- Newcastle's only victory in the past 32 Premier League meetings was by 2-1 at home in January 2019 (D5, L26).