Newcastle United strikers Aleksandar Mitrovic and Dwight Gayle miss out with concussion following Tuesday's EFL Cup win against Cheltenham.
Ayoze Perez could feature up front on his own, but winger Rolando Aarons is also absent after he fractured a metatarsal in his foot.
Bruno is expected to replace Brighton right-back Liam Rosenior, who misses out with an ankle injury.
One of Uwe Hunemeier or Rohan Ince are likely to fill in at centre-back.
Boss Chris Hughton will make a decision whether to include midfielder Dale Stephens, who has been the subject of transfer interest from Burnley.