Manchester City's Bernardo Silva is set to return to the squad after missing the Uefa Super Cup win against Sevilla on Wednesday through illness.
Kevin de Bruyne could be out for up to four months following the hamstring injury he suffered against Burnley in City's opening league game.
Newcastle's Emil Krafth, Javier Manquillo and Joe Willock remain on the sidelines.
Head coach Eddie Howe has no other injury concerns amongst his squad.
MATCH FACTS
Head-to-head
- Manchester City's only defeat in their last 31 Premier League games against Newcastle (W25, D5) was a 2-1 loss at St James' Park in January 2019.