Luton midfielder Marvelous Nakamba is suspended after picking up five yellow cards.
Forward Cauley Woodrow returned to training last week after a calf injury and could be available.
Newcastle forward Alexander Isak, who has an ongoing groin issue, is "50/50" to play, according to head coach Eddie Howe.
Fabian Schar and Joelinton are hoping to feature while Emil Krafth and Anthony Gordon will also be assessed.
MATCH FACTS
Head-to-head
- This is the first league meeting between Luton Town and Newcastle United since 1993, and the first in the top flight since 1989.