Alan Browne begins a suspension for Preston but boss Simon Grayson will have three men back for Newcastle's visit to Deepdale.
Midfielder Browne incurred a three-match ban when he was dismissed during North End's 6-0 drubbing by the Magpies on Tuesday night.
Marnick Vermijl and Alex Baptiste are available for this Sky Bet Championship fixture having been cup-tied while Aiden McGeady (hamstring) is also set to return.
Grayson is still unable to call on John Welsh (calf), Stevie May and Calum Woods (both knee).
Newcastle boss Rafael Benitez is likely to turn to his big guns once again after making seven changes for Tuesday night's EFL Cup rout.
Alan Browne banned as Preston welcome Newcastle
