All odds via FanDuel Sportsbook
- Green Bay Packers @ Detriot Lions: -7.5
- Washington Commanders @ Dallas Cowboys: -12.5
- San Francisco 49ers @ Seattle Seahawks: +7
- Miami Dolphins @ New York Jets: +9.5
- New England Patriots @ New York Giants: +3.5
- Pittsburgh Steelers @ Cincinnati Bengals: +1.5
- Carolina Panthers @ Tennessee Titans: -4
- Jacksonville Jaguars @ Houston Texans: +1.5
- New Orleans Saints @ Atlanta Falcons: -1.5
- Tampa Bay Buccaneers @ Indianapolis Colts: -2.5
- Los Angeles Rams @ Arizona Cardinals: -1.