All odds via ESPN BET
- Los Angeles Chargers @ Green Bay Packers: +3
- Tennessee Titans @ Jacksonville Jaguars: -6.5
- Las Vegas Raiders @ Miami Dolphins: -13.5
- Dallas Cowboys @ Carolina Panthers: +10.5
- Arizona Cardinals @ Houston Texans: -5.5
- Pittsburgh Steelers @ Cleveland Browns: +1
- New York Giants @ Washington Commanders: -9
- Chicago Bears @ Detroit Lions: -8
- Tampa Buccaneers San Francisco 49ers: -13
- New York Jets @ Buffalo Bills: -7.5
- Seattle Seahawks @ Los Angeles Rams: +2
- Minnesota Vikings @ Denver Broncos: -3
- Philadelphia Eagles @ Kansas City Chiefs: -2.