Each NFL offense is granted around 60 plays per game. So, an offense typically gets an average of 60 plays, while special teams usually account for 20 additional plays in total (both teams combined).
That amounts to about 140 plays per game and a feeling of what should be impending doom whenever one play isn’t executed properly.
As the old coaching saying goes, “I can live with physical mistakes as long as the preparedness is on point,” (I’m paraphrasing, of course), each football play is precious in its own right—no matter the game, season or record of the two teams involved.