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Who will be the New York Giants’ X-Factors when they face the 49ers?

The New York Giants will look to get their first win of the season when they take on the injury-ravaged San Francisco 49ers in Week 3.

As bad as the injury bug has hit the Giants with the losses of Saquon Barkley and Sterling Shepard, it’s nothing compared to the 49ers’ health-related setbacks. Jimmy Garoppolo, Raheem Mostert, George Kittle, Tevin Coleman, Dee Ford, and Dre Greenlaw have already been ruled out for Sunday’s game. This is in addition to Nick Bosa, Solomon Thomas, and Richard Sherman hitting injured reserve.

Despite all of the injuries they suffered, the defending NFC champions are favored to win their second game in as many weeks at MetLife Stadium.