The Week 1 games in the NFL are the most unpredictable, so bettors beware. There are so many new faces in new places, new schemes and regimes, that you really don't have a sense of things until the end of September. Last season five underdogs opened the season by winning outright, and the belief here is that number could be duplicated to start 2018. Look out for teams trying to start fresh after bad years, and teams with new coaches.
And remember, I pick every game so that you don't have to. Pick your spots wisely.
My most-confident picks ATS: Giants, Broncos, Bears, Texans and Ravens.