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Giants vs. 49ers Betting Preview: Odds, Picks, Predictions

The New York Giants enter their Week 3 matchup with the San Francisco 49ers at 0-2. Let’s take a look at the Giants vs. 49ers odds to see how things stack up.

Big Blue has endured a rough start to the 2020 regular season, losing two straight and having star running back Saquon Barkley suffer a torn ACL. Nonetheless, the team will look to bounce back against the 49ers in Week 3.

Preview

Initially, almost everyone believed this game would be an automatic loss for the Giants. They have one of the worst offenses in the league with a putrid offensive line going up against the defending NFC champions, a squad full of talent.