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Giants-Bills opening odds: Bills are massive 14.5-point favorites

’ disastrous season got even worse Sunday, when quarterback Daniel Jones was helped off the field with a neck injury during a 31-16 loss to the Miami Dolphins (-14). With his status still uncertain, oddsmakers aren’t giving the 1-4 Giants much of a chance to upset the Buffalo Bills (-14.5) on the road next week.

New York opened as 14.5-point underdogs at DraftKings Sportsbook with +600 odds on the moneyline. The over/under is set at just 46.5 points.

If the line holds, it’ll be tied for the largest point spread for any game so far this season.