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Giants at 49ers, Week 3: Everything you need to know

(1-1) complete their two-game West Coast swing on Thursday night against the 2-0 . Game time is 8:15 p.m. ET on Amazon Prime. The early line from DraftKings Sportsbook has the Giants as 10.5-point underdogs.

The Giants will be without star running back Saquon Barkley, out for at least two games due to an ankle injury suffered in Sunday’s comeback victory over the Arizona Cardinals (+12)

. In two games, Barkley has 29 carries for 114 yards (3.9 yards per carry). Matt Breida has three carries for 14 yards and Gary Brightwell one carry for 5 yards.