David Villa makes his 100th MLS appearance for NYCFC in the 2018 Home Opener vs. LA Galaxy.
El Guaje will look to add to his 65 goals for the Club when Sigi Schmid's men come to town for the first Bronx battle of the year.
READ: Major Keys to NYCFC vs. LA Galaxy
Elsewhere, new signing from USL Affiliate San Antonio Sebastien Ibeagha makes his first start for the Club, coming in to replace Maxime Chanot who is suspended.
The Luxembourg international defender sits out for one game following his late red card in the 2-0 season-opening win over Sporting KC last weekend.