(5-5) continue their gauntlet portion of their schedule, this time hosting the Buffalo Bills (-4.5) (6-4) in New Orleans on Thanksgiving.
The Saints are have dealt with injuries all season, most recently dealing with additional injuries on offense in the form of Alvin Kamara, Terron Armstead, and Ryan Ramczyk. Jameis Winston, Michael Thomas, and Wil Lutz are all still out for the rest of the season.
The Buffalo Bills were upset last week by the Indianapolis Colts (+2.5)
41-15, but still bring a ton of firepower in the Dome. Quarterback Josh Allen and wide receivers Stefon Diggs and Emmanuel Sanders should be playing with something to prove after a disappointing performance against the Colts.