After a rebound win at home against the defending Super Bowl champs, the New Orleans Saints (+8)
are looking to string back-to-back wins together for the first time in 2022. According to DraftKings Sportsbook, the Saints might have a tough go of it, though, considering they open as 8.5-point road underdogs against their Week 12 opponent, the San Francisco 49ers (-10).
The Saints might be coming off a 7-point win over the Rams, but the 49ers have played the Rams twice already this season with an average point differential of 16 (beating the Rams 24-9 and 31-14).