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NFL picks vs. the spread, Week 1: Patriots begin quest for 5th Super Bowl title in the desert

The NFL is back. It's bigger, better and more unpredictable than ever.

With Tom Brady's suspension in New England and 15 rookies on the roster in Seattle, this feels like a wide open season.

'It will be a little different.'

Las Vegas bookmakers have installed the Patriots as 6-1 favorites to win Super Bowl LI in Houston, with the Cardinals, Packers and Seahawks pegged as second choices at 8-1.Thirteen teams are grouped between 10-1 and 30-1.

Unpredictability continues to rule the NFL.

Last year, 131 NFL games (51.2 percent) were decided by seven points or fewer, the most of any season in league history.