The New Orleans Saints were without starting offensive linemen Erik McCoy (calf) and Terron Armstead (elbow) on the initial New York Giants injury report, while Jameis Winston was a full participant with a new knee injury. The full report from both teams:
| Player | Wednesday | Thursday | Friday | Game Status |
| OL Ben Brederson, hand | DNP | |||
| WR Sterling Shepard, hamstring | DNP | |||
| WR Darius Slayton, hamstring | DNP | |||
| RB Saquon Barkley, knee | Limited | |||
| DB Keion Crossen, elbow | Limited | |||
| FB Cullen Gillaspia, ankle | Limited | |||
| DB Logan Ryan, hamstring | Limited |
