4:25 p.m. ET | FOX
Matchup rating: 76.2 | Spread: NO -3.5 (49)
What to watch for: It's a matchup for the ages in Tom Brady against Drew Brees. This will be the first game in NFL history with two starting QBs over 40 years old, and both teams are decidedly "Super Bowl or bust" because of it. Brees has not officially declared this as his last season but acknowledged this week, "I'm on borrowed time. I've got nothing to lose, so I'm turning it loose.