Monday, 8:15 p.m. ET | ESPN
Matchup rating: 51.5 | Spread: NO -8 (51)
What to watch for: This will be a fun quarterback duel between 20-year veteran Drew Brees and rookie Justin Herbert. But what really defines this matchup, unfortunately, is the overwhelming amount of injuries that have plagued both teams. The Saints could potentially get Michael Thomas back from his Week 1 ankle injury. Meanwhile, the Chargers just lost dynamic running back Austin Ekeler for 4-6 weeks with a hamstring injury.