ESPN.com · Sep 14, 2025
49ers vs. Saints: Week 2 NFL game highlights
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NEW ORLEANS -- The San Francisco 49ers face the New Orleans Saints in a NFL Week 2 matchup on Sunday.
The 49ers (1-0) opened their season with a road victory against the NFC West rival Seahawks. San Francisco faces quarterback questions entering the game, as backup Mac Jones is expected to start for Brock Purdy, who suffered left shoulder and toe injuries in Week 1. The Saints (0-1) lost to the Cardinals in their season opener and are looking for their first victory under coach Kellen Moore.
