SANTA CLARA, Calif. -- The Arizona Cardinals will be without quarterback Kyler Murray and wide receiver DeAndre Hopkins against the San Francisco 49ers on Sunday.
Both players were ruled inactive about 90 minutes before kickoff at Levi's Stadium.
This will be the first game in Murray's three-year career that he's missed and the third game Hopkins has missed in his nine-year career.
Colt McCoy will get the start at quarterback with Murray sidelined.
Murray is still dealing with a sprained left ankle that he suffered late in the Cardinals' loss to the Green Bay Packers on Oct.