ALBUQUERQUE, N.M. — Siakam was 7 of 11 from the field and has only missed a double-double in three games for the Aggies (15-8, 7-1) this season.
Ian Baker added 13 points and Johnathon Wilkins had 12 as NMSU made 27 of 50 shots for 54 percent while outrebounding the Antelopes 44-26.
The Aggies increased a five-point halftime lead to double figures with 12:40 left and an 8-0 run made it a 21-point advantage with 4:30 remaining.
DeWayne Russell and Joshua Braun had 12 points each for Grand Canyon (19-4, 6-2), which shot under 30 percent and has lost its last two games after winning 12 in a row.