The Patriots announced they placed center David Andrews and linebacker Josh Uche on injured reserve Saturday.
Andrews has a thumb injury and Uche a foot injury. They will miss games against the Raiders, Chiefs and Broncos before they become eligible to return to action.
The Patriots signed offensive lineman James Ferentz to the 53-player roster off their practice squad and promoted defensive lineman Nick Thurman and receiver Isaiah Zuber.
Ferentz, a five-year veteran, could start. He has played 38 regular-season games with two starts.
Zuber, an undrafted rookie, becomes the fifth receiver behind N’Keal Harry, Damiere Byrd, Julian Edelman and Jakobi Meyers.