The New England Patriots will forever be able to brag about being the first team to defeat Patrick Mahomes in the postseason, preventing the Chiefs from reaching three straight Super Bowls from 2018-20. Tom Brady was the quarterback of that Patriots team that escaped Arrowhead with an overtime win, and then went on to defeat the Los Angeles Rams in the Super Bowl. Two seasons later, Brady and the Tampa Bay Buccaneers beat the Chiefs handedly in the Super Bowl.
Brady and Joe Burrow are the only AFC quarterbacks to defeat Mahomes and the Chiefs in the postseason, and Brady is the only quarterback to defeat Mahomes twice in the playoffs.