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New England Patriots vs. Buffalo Bills Betting Odds, Analysis, NFL Pick

The Buffalo Bills (1-0) have earned a lot of respect from oddsmakers following their impressive season-opening victory against the Indianapolis Colts and hope to make it two straight wins when they host the New England Patriots (1-0) on Sunday. This AFC East matchup is set as a close one on the odds despite the fact that the defending Super Bowl champion Patriots have won 26 of the past 29 meetings with the Bills.

Point spread: Patriots opened as 1.5-point favorites; the total was 46 early in the week, according to sportsbooks monitored by Odds Shark.