England head coach Steve Borthwick has dropped veterans Billy Vunipola, Jonny May and Jack Nowell for his first Six Nations squad.
Borthwick has jettisoned three established performers under his predecessor Eddie Jones, who was sacked last month and has now been appointed Australia boss.
Number eight Vunipola and wings May and Nowell were all involved in the 27-13 defeat by South Africa that concluded the autumn and spelt the end of the Jones era.
While the trio are not part of the 36-man squad that will next week begin preparations for the Six Nations opener against Scotland on February 4, there are recalls for Dan Cole and Elliot Daly.