According to the betting market, there hasn't been this large of gap between the best and worst teams in the NFL since 1987, a strike season featuring games with starters against replacement players.
The New England Patriots are 22.5-point favorites over the New York Jets, and the Dallas Cowboys are 21.5-point favorites over the Miami Dolphins at the majority of sportsbooks.
According to ESPN Stats & Information, it's the first time there has been a week with multiple 20-point spreads in 32 years. In Week 5 of the 1987 season, the Dallas Cowboys were favored by 21 over the Philadelphia Eagles, and the San Francisco 49ers were 23-point favorites at the Atlanta Falcons.