NEW ENGLAND PATRIOTS (2-4) VS. SAN FRANCISCO 49ERS (3-3)
Sunday, October 25, 2020 at 4:25 p.m. ET. Gillette Stadium.
The New England Patriots will attempt to get back to a .500 record this week when they host the defending NFC Champion San Francisco 49ers. The Patriots will face an NFC opponent for the second time this season, following 35-20 loss at Seattle in Week 2. Since the NFL realignment in 2002, the Patriots have the best inter-conference record with a 58-15 (.795) mark. The 2019 Patriots were 4-0 against the NFC East. In addition to the 49ers, the Patriots will host Arizona on Nov.