The favorite is 8-2 straight up over the last 10 meetings between Notre Dame and Stanford, but the underdog is 7-3 against the spread during that span as the teams have played a bunch of close games over recent seasons. The Irish will go off as the underdog for Saturday night's clash with the Cardinal out on the Farm.
Point spread: Fighting Irish opened as two-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 36.8-33.7 Cardinal
Why the Notre Dame Fighting Irish can cover the spread
Notre Dame extended its winning streak to six games with a 19-16 victory over Boston College Saturday night at Fenway Park.