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College Football Picks Week 5: Predictions and Odds for Top 25 Schedule

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Conference play continues to ramp up in Week 5 of the college football season with several intriguing battles that could have a big impact on the rankings.

In a sport where one loss can change a season, several College Football Playoff contenders will be on high alert with tough matchups throughout the upcoming weekend. Even the games that don't feature two ranked teams could create some major surprises.

Here are predictions from the top games of the week.

No. 5 USC at No. 16 Washington State

In this quarterback battle, the less famous starter could be the key to victory.