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College Football Picks Week 5: Odds, Predictions, Schedule, Rankings for Top 25

Related Topics: Quinn Ewers

The Notre Dame Fighting Irish have to find a way to bounce back after their heartbreaking home loss to the Ohio State Buckeyes in Week 4.

Sam Hartman and Co. hit the road to face the Duke Blue Devils in a game that carries much more significance that it did at the start of the season.

Duke can make an argument that it is the second-best team in the ACC behind the Florida State Seminoles.

The Blue Devils beat the Clemson Tigers at home in Week 1 and they earned the right to host College GameDay for the first time in Durham.