I don't think I need to dive into too much detail here. The Saints are awful on defense. They are 31st in the NFL in pass defense, giving up over 280 yards per game, but even worse on run defense. On the ground, the Saints defense gives up a whopping 140 yards per game, which is last in the NFL.
The Bucs are as healthy as they have been all season on offense. Jameis Winston will have all of his key weapons for the 2nd straight game, and the offensive line is still standing strong, even with Demar Dotson filling in for Gosder Cherilus.