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49ers lose on last-second TD

Robert Deutsch-USA TODAY Sports

The 49ers were dealt a crushing loss in the final minute of Sunday night's game.

EAST RUTHERFORD, New Jersey - Larry Donnell's 12-yard touchdown catch over NaVorro Bowman thwarted what could have been the 49ers' second win of the season.

The 49ers put together their best all around performance since their season opening win over the Vikings, only to have Eli Manning deal Jim Tomsula's a heart-wrenching loss with his second touchdown pass of the game, coming with 20 seconds remaining.

San Francisco was behind for most of the game, until they took a lead late in the fourth quarter.