With a win over the Texans on Oct. 8, the Colts currently have the tie-breaker advantage over Houston, making this as close to a make-or-break game for the AFC South rivals.
The Texans got back into contention with a four-game winning streak in November, but two straight losses have them on the outside of the projected AFC playoff teams and realistically needing to win the division to make the postseason.
After Brian Hoyer helped lead the Texans back into contention, he has been ruled out against the Colts with a concussion, sending T.J. Yates into the spotlight.