NFL Week 6 picks, predictions, schedule, odds, fantasy tips

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The Week 6 NFL schedule for the 2025 season brings some intriguing matchups.

After a 206-yard rushing game last week, Panthers RB Rico Dowdle will look to have a repeat performance against the Cowboys, his former team. The Bucs will host the 49ers for a showdown between 4-1 teams. And the Lions visit the Chiefs' Arrowhead Stadium for the second time in three seasons.

We have you covered with everything you need to know. Our NFL Nation reporters take you inside the locker room with the best thing they heard this week, and ESPN Research provides a key stat to know and a betting nugget for each contest. Plus, analytics writer Seth Walder makes a bold prediction for each…