Mackenzie Dern will headline the UFC 321 co-main event on October 25, 2025, at the Etihad Arena in Abu Dhabi when she faces Virna Jandiroba for the vacant women’s strawweight championship. The title was left open when former champion Zhang Weili moved up to flyweight to challenge Valentina Shevchenko.
In a recent, Dern acknowledged that she would not be ready to face Zhang at this point in her career but expressed confidence that winning the belt would change that trajectory.
Mackenzie Dern Targets Zhang Weili Title Fight at UFC White House Event
Dern and Jandiroba first met in December 2020, with Dern earning a unanimous decision win.