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Butler Bulldogs vs. Villanova Wildcats Betting Odds, College Basketball Pick

Chris Szagola/Associated Press

The second-ranked Villanova Wildcats (26-2, 13-2 Big East) can clinch the top seed in the conference tournament by avenging one of their two losses Wednesday when they host the 22nd-ranked Butler Bulldogs (21-6, 10-5) as big home chalk.

The defending national champion Wildcats fell to the Bulldogs 66-58 as two-point road favorites back on January 4 following a 14-0 start.

Point spread: The Wildcats opened as 9.5-point favorites, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)

Why the Bulldogs can cover the spread

Butler found a way to upset Villanova in the first meeting and can definitely stay within double digits here.