Óscar Pareja's side defeated the Liga MX champions on penalties to progress to the semi-finals, where yet another meeting with Florida rivals Inter Miami awaits.
Still riding high from their recent Clausura and Campeón de Campeones titles, both coming with wins over Club América, Toluca were considered the firm favourites to lift this summer's installment of Leagues Cup. That was until Orlando City spoilt the party.
After ninety, cagey minutes of the quarter-final showdown in Carson, California, in which the Central Floridians registered the game's only shot on target, both teams began the critical penalty shootout with five faultless spot kicks.