Two sets of divisional rivals will square off in the American League division series.
The Tampa Bay Rays and New York Yankees play each other, while the Houston Astros and Oakland Athletics square off.
The main difference from the 10 regular-season meetings between the clubs is the ALDS games will occur in bubbles in California.
San Diego will play host to the Rays and Yankees. The pair of AL West foes will face off at Dodger Stadium in Los Angeles.
Tampa Bay and Oakland won their respective regular-season series, but it will not be easy for either team to replicate that success given how well New York and Houston performed in the wild-card round.